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Baclofen use in narcolepsy with cataplexy therefore warrants further investigation. We performed a review of literature (MEDLINE and EMBASE database), without limited date or publication restrictions (N1) Narcolepsy w/ Cataplexy I tried baclofen a few times and it made me a zombie the next day, even at low doses… not even my stims could shake off the zombieness. The phase IV clinical study analyzes which people take Baclofen and have Narcolepsy. In this review, we described few conditions of cataplexy not related to narcolepsy. 002 Article Download PDF View Record in Scopus Google Scholar. Disclosure The authors report no conflicts of interest in this work Therefore, it is essential disconnecting cataplexy from narcolepsy especially in pediatric population and after use of a few medications. A recent report of a murine model of narcolepsy-cataplexy suggests R-baclofen has potential efficacy against cataplexy Currently there is no cure for narcolepsy, so treatment focuses on control of symptoms. (2) Although the sympathomimetic stimulants, such as amphetamines or methylphenidate, are effective in improving excessive daytime sleepiness in patients with narcolepsy, they have the potential for dependence, have sometimes disabling sympathomimetic side-effects and are associated with tolerance. 8 milligram per kilogram twice nightly — the same dosing regimen given to people with narcolepsy — suppressed cataplexy to a greater extent. The investigators concluded that future studies are warranted,. A 2014 mice study found that giving R-baclofen (R-BAC) 2. The burden of narcolepsy with cataplexy: how disease history and clinical features influence socio-economic outcomes Sleep Med , 13 ( 10 ) ( 2012 ) , pp. Ago Narcolepsy & Cataplexy Not a good idea if you have an apnea or respiratory matter, as it is a respiratory depressant, which can be a danger. Background: Narcolepsy is a disabling sleep-wake disorder characterized by the pentad symptoms of excessive daytime sleepiness, sleep paralysis, sleep fragmentation, sleep-related hallucinations, and cataplexy. Cataplexy treatments include antidepressants or a GABA-B agonist, gamma hydroxybutyrate (GHB). Adverse effects associated with the use of baclofen include depression, hallucinations, dizziness, sensory disturbances, and nausea. 22, 30, 31 Huang and Guilleminault evaluated the relative response to SO versus baclofen in a cohort of adolescent patients with narcolepsy and cataplexy Summary: Narcolepsy is found among people who take Baclofen, especially for people who are female, 50-59 old. Our findings suggest that baclofen could be helpful for cataplexy at moderate night-time doses, possibly in older non-adolescent patients and could be a safer and cheaper alternative to GHB. Chronic dosing with R-BAC promoted NREM sleep time, intensity, and consolidation during the light period, longer bouts of wakefulness during the dark period, and sustained suppression of REM sleep and cataplexy. We performed a review of literature (MEDLINE and EMBASE database), without limited date or publication restrictions The burden of narcolepsy with cataplexy: how disease history and clinical features influence socio-economic outcomes Sleep Med , 13 ( 10 ) ( 2012 ) , pp. These therapies can be limited in some patients because of inadequate efficacy, poor tolerability, or side effects. First-line options include Modafinil/Armodafinil (for excessive daytime sleepiness, EDS), Sodium Oxybate (for EDS and/with cataplexy. GHB is the most effective treatment for cataplexy, but is expensive and can have significant side effects. Alternatively, sodium oxybate can be used nightly for improved cataplexy, sleep consolidation, and following day wakefulness. Currently there is no cure for narcolepsy, so treatment focuses on control of symptoms. There is no curative therapy for narcolepsy. Treatment is therefore symptom directed Our findings suggest that baclofen could be helpful for cataplexy at moderate night-time doses, possibly in older non-adolescent patients and could be a safer and cheaper alternative to GHB. Studies evaluating clinically available baclofen as a treatment for narcolepsy with cataplexy in humans have not shown consistent benefit.
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